Nebivolol hydrochloride ( Nebivolol HCl; Nebivolol Hydrochloride; Silostar; Bystolic, R-67145; R 67145; R67145 )

Catalog No. M12131 CAS No. 152520-56-4

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HPLC

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Product Name

Nebivolol hydrochloride
Note

Research use only, not for human use.
Brief Description

Nebivolol hydrochloride selectively inhibitsβ1- adrenergic receptor withIC50of 0.8 nM.
Description

Nebivolol hydrochloride selectively inhibitsβ1- adrenergic receptor withIC50of 0.8 nM.
Synonyms

Nebivolol HCl; Nebivolol Hydrochloride; Silostar; Bystolic, R-67145; R 67145; R67145
Pathway

Endocrinology/Hormones
Target

Adrenergic Receptor
Recptor

β1-adrenoceptor
Research Area

Cardiovascular Disease
Indication

——

CAS Number

152520-56-4
Formula Weight

441.90
Molecular Formula

C22H25F2NO4·HCl
Purity

>98%(HPLC)
Solubility

DMSO: 88 mg/mL (199.14 mM)
SMILES

O[C@@H]([C@H]1CCC2=C(O1)C=CC(F)=C2)CNC[C@H](O)[C@@H]3CCC4=C(O3)C=CC(F)=C4.[H]Cl
Chemical Name

(R)-1-((R)-6-fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol hydrochloride

1.Pauwels PJ, et al. Mol Pharmacol, 1988, 34(6), 843-85

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